FrederickRecruiter Since 2001
the smart solution for Frederick jobs

Scientist I - Structural Biology ( X-ray crystallography) (req1845)

Company: Frederick National Laboratory
Location: Frederick
Posted on: July 15, 2021

Job Description:

KEY ROLES/RESPONSIBILITIES

Scientist I - Structural Biology

  • The candidate will join the structural biology group within the RAS initiative and will be responsible for the crystallization and the structure determination of protein-small molecule and protein-protein complexes by X-ray crystallography
  • The work will include construct design, biochemical and biophysical characterization, crystallization, X-ray data collection, structure determination, and analysis
  • The candidate will work closely with protein scientists, biophysicists, and protein NMR scientists as part of an integrated structural biology effort
  • The candidate will be a member of the drug discovery team, working closely with computational and medicinal chemists on structure-based drug design approaches for small molecule agent optimization. The candidate will be expected to be able to participate in experimental design and to conduct experiments in a priority-driven environment independently
  • The candidate will be responsible for completing projects independently and as part of a team and will be responsible for timely updates of the project progress to their supervisor both informally and by formal report writing
  • Work requires the use of personal protective equipment and adherence to strict safety protocols

BASIC QUALIFICATIONS
  • Possession of a PhD degree in structural biology, protein biochemistry/biophysics, crystallography, or in a related discipline from an accredited college or university, according to the Council for Higher Education Accreditation
  • Proven ability in all aspects of protein crystallography from construct design through structure determination and analysis
  • Experience in the crystallization of protein-small molecule and protein-protein complexes
  • Expertise in commonly used structural biology software packages
  • Proficiency in protein biochemical and biophysical assays
  • Excellent communication and witting skills
  • Detail-oriented, highly organized and able to manage multiple tasks and deliver quality data
  • Must be able to obtain and maintain a clearance

PREFERREDQUALIFICATIONS
  • Experience in analyzing protein small-molecule interaction using isothermal titration calorimetry (ITC), differential scanning fluorimetry (DSF), and NMR techniques
  • Knowledge of mechanistic enzymology, and protein chemistry

JOB HAZARDS
  • This position is subject to working with radioactive material and requires to become an approved radiation worker


Keywords: Frederick National Laboratory, Frederick , Scientist I - Structural Biology ( X-ray crystallography) (req1845), Other , Frederick, Maryland

Click here to apply!

Didn't find what you're looking for? Search again!

I'm looking for
in category
within


Log In or Create An Account

Get the latest Maryland jobs by following @recnetMD on Twitter!

Frederick RSS job feeds