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Scientist I - Structural Biology ( X-ray crystallography) (req1845)

Company: Frederick National Laboratory
Location: Frederick
Posted on: July 15, 2021

Job Description:


Scientist I - Structural Biology

  • The candidate will join the structural biology group within the RAS initiative and will be responsible for the crystallization and the structure determination of protein-small molecule and protein-protein complexes by X-ray crystallography
  • The work will include construct design, biochemical and biophysical characterization, crystallization, X-ray data collection, structure determination, and analysis
  • The candidate will work closely with protein scientists, biophysicists, and protein NMR scientists as part of an integrated structural biology effort
  • The candidate will be a member of the drug discovery team, working closely with computational and medicinal chemists on structure-based drug design approaches for small molecule agent optimization. The candidate will be expected to be able to participate in experimental design and to conduct experiments in a priority-driven environment independently
  • The candidate will be responsible for completing projects independently and as part of a team and will be responsible for timely updates of the project progress to their supervisor both informally and by formal report writing
  • Work requires the use of personal protective equipment and adherence to strict safety protocols

  • Possession of a PhD degree in structural biology, protein biochemistry/biophysics, crystallography, or in a related discipline from an accredited college or university, according to the Council for Higher Education Accreditation
  • Proven ability in all aspects of protein crystallography from construct design through structure determination and analysis
  • Experience in the crystallization of protein-small molecule and protein-protein complexes
  • Expertise in commonly used structural biology software packages
  • Proficiency in protein biochemical and biophysical assays
  • Excellent communication and witting skills
  • Detail-oriented, highly organized and able to manage multiple tasks and deliver quality data
  • Must be able to obtain and maintain a clearance

  • Experience in analyzing protein small-molecule interaction using isothermal titration calorimetry (ITC), differential scanning fluorimetry (DSF), and NMR techniques
  • Knowledge of mechanistic enzymology, and protein chemistry

  • This position is subject to working with radioactive material and requires to become an approved radiation worker

Keywords: Frederick National Laboratory, Frederick , Scientist I - Structural Biology ( X-ray crystallography) (req1845), Other , Frederick, Maryland

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