Scientist I, Biochemist

Company: Frederick National Laboratory for Cancer Research
Location: Frederick
Posted on: January 8, 2020

Job Description:

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise. KEY ROLES/RESPONSIBILITIES Work in a fast-paced environment, providing biochemical and biophysics support to the FNL/NCI RAS Initiative Perform SPR experiments to evaluate small molecule binding activity to RAS and related proteins, in collaboration with chemists, structural biologists and computational scientists. Perform plate based biochemical assays, such as alpha and trFRET assays to evaluate activity of small molecule inhibitors Work independently, however within highly collaborative team environment Stay informed of the latest findings in biochemical/biophysical assay and cancer drug discovery BASIC QUALIFICATIONS Possession of a doctorate degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency. No work experience required beyond the Doctorate degree Working knowledge of biochemical and biophysical assay to measure protein:protein and protein:small molecule interactions Experience in plate-based protein binding assays Must be able to obtain and maintain a security clearance PREFERRED QUALIFICATIONS Experience with SPR to measure protein:small molecule interactions Experience with biochemical assays to measure small molecule activity on protein interactions Familiarity with modern protein analytical technologies such as: FPLC (Fast Protein Liquid Chromatography), Dynamic Light Scattering, Circular dichroism Highly collaborative, excellent communication skills, self-motivation, team-oriented individual Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

Keywords: Frederick National Laboratory for Cancer Research, Frederick , Scientist I, Biochemist, Other , Frederick, Maryland