Scientist I, Biomolecular NMR Spectroscopy

Company: Frederick National Laboratory for Cancer Research
Location: Frederick
Posted on: January 7, 2020

Job Description:

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise. KEY ROLES/RESPONSIBILITIES The RAS Initiative is seeking a hands-on biomolecular NMR spectroscopist to work on protein-ligand interaction analysis, small molecule screening, and structure determination/refinement by NMR The candidate will join the RAS structural biology group within the RAS initiative and will help in maintaining the in-house NMR spectrometer The candidate will be working closely with a highly collaborative team of biophysicists, chemists, biochemists, cell, and molecular biologists to gain new structural insights about the RAS biology as well as on structure-based drug design approaches for small molecule agent optimization The candidate is expected to be able to participate in experimental design and conduct experiments in a priority-driven environment The candidate will be responsible for completing projects independently and as part of a team Work requires the use of personal protective equipment and adherence to strict safety protocols Structure determination by 3D-NMR, structure refinement by NMR, protein-ligand interactions by NMR, small molecule screening by NMR BASIC QUALIFICATIONS Possession of a Ph.D. degree in structural biology, protein biophysics, biomolecular NMR, or in a related discipline from an accredited college or university according to the Council for Higher Education Accreditation. field (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency. No experience required beyond the doctorate degree Familiarity with structure determination by NMR and multidimensional NMR techniques Ability to provide NMR support for protein/small molecule interaction analysis Experience designing and conducting NMR experiments, collect and analyze data Familiarity with linux platform and NMR structural biology software such as NMRPipe, Sparky, Xplor-NIH, etc. Detail-oriented, highly organized and excellent communication skills Must be able to obtain and maintain a security clearance PREFERRED QUALIFICATIONS Post-doctoral experience in protein NMR Experience with NMR structure determination and SAR by NMR Biomolecular NMR experience (complete NMR assignments of at least one protein) Protein-ligand interactions by NMR Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

Keywords: Frederick National Laboratory for Cancer Research, Frederick , Scientist I, Biomolecular NMR Spectroscopy, Other , Frederick, Maryland